Synthesis of 9Z-9-substituted retinoic acids by palladium catalyzed coupling reaction of a vinyl triflate with alkenyl stannanes.
نویسندگان
چکیده
Palladium catalyzed cross coupling reactions of a vinyl triflate intermediate and various alkenyl stannanes afforded trisubstituted Z-olefins stereoselectively in high yields. These olefins were then converted to the corresponding 9Z-retinoic acids via Horner-Emmons reaction and subsequent basic hydrolysis in excellent yields.
منابع مشابه
Heck Coupling with Nonactivated Alkenyl Tosylates and Phosphates: Examples of Effective 1,2-Migrations of the Alkenyl Palladium(II) IntermediatesWe thank the Danish National Science Research Council, the Carlsberg Foundation, and the University of Aarhus for generous financial support of this work
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ورودعنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 48 9 شماره
صفحات -
تاریخ انتشار 2000